Premium
The mechanism of replication of hepatitis B virus: Evidence of asymmetric replication of the two DNA strands
Author(s) -
Fowler M. J. F.,
Monjardino J.,
Tsiquaye K. N.,
Zuckerman A. J.,
Thomas H. C.
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130110
Subject(s) - virology , hepatitis b virus , hepatitis b virus pre beta , biology , dna replication , replication (statistics) , duck hepatitis b virus , replication factor c , hepatitis b virus dna polymerase , viral replication , reverse transcriptase , dna , control of chromosome duplication , virus , viral transformation , hepadnaviridae , genetics , gene , polymerase chain reaction
In this study we have characterised the DNA replicative intermediates of hepatitis B virus and have shown that HBV‐DNA replication is asymmetric. This pattern of HBV replication is similar to that reported for the related duck hepatitis virus (DHBV) and suggests the involvement of a similar reverse transcription process in HBV‐DNA replication.