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Experimental infection of chimpanzees with the HBsAg‐Associated delta (δdL) agent: An ultrastructural study
Author(s) -
Canese Maria G.,
Rizzetto Mario,
Novara Rosanna,
London William T.,
Purcell Robert H.
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130108
Subject(s) - ultrastructure , virology , hbsag , cytoplasm , electron microscope , antigen , biology , inoculation , virus , hepatitis b virus , immunology , microbiology and biotechnology , physics , anatomy , optics
Characteristic cytoplasmic membranous structures and intranuclear aggregates of particles similar to those reported in non‐A, non‐B hepatitis were observed by electron microscopy in the liver biopsies of chimpanzees inoculated with human serum, infectious for the delta agent. The ultrastructural changes were maximal during the intrahepatic production of the δdL antigen, but were detected also independently of δdL‐Ag expression. The ultrastructural analogies provide further evidence that δdL has properties distinct from HBV.