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Mixed infection with human cytomegalovirus and human polyomavirus (BKV)
Author(s) -
Goldstein Simoy C.,
Tralka Tommie S.,
Rabson Alan S.
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130104
Subject(s) - human cytomegalovirus , virology , biology , cytomegalovirus , embryo , bk virus , cell culture , virus , herpesviridae , kidney , viral disease , kidney transplantation , genetics , endocrinology , microbiology and biotechnology
Mixed infection, the infection of a single cell by two distinguishable viruses, has been demonstrated electron microscopically in human embryo lung (HEL) and human embryo kidney (HEK) cells infected with human cytomegalovirus (HCMV) and human polyomavirus (BKV). There was no evidence of enhancement of HCMV by BKV in either cell system; however, in HEL cells under certain conditions, HCMV enhanced the growth rate of BKV. Since both BKV and HCMV are often found in the urine of immunosuppressed patients, the enhancement of BKV by HCMV may be of clinical significance.