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Failure to detect nucleic acid homology between some non‐A, Non‐B viruses and hepatitis B virus DNA
Author(s) -
Fowler M. J. F.,
Monjardino J.,
Weller I. V.,
Bamber M.,
Karayiannis P.,
Zuckerman A. J.,
Thomas H. C.
Publication year - 1983
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890120306
Subject(s) - nucleic acid , virology , hepatitis b virus , dna , biology , hepatitis b virus dna polymerase , homology (biology) , hepatitis b virus pre beta , hepatitis b , hepadnaviridae , nucleic acid thermodynamics , hepatitis , virus , microbiology and biotechnology , amino acid , genetics , base sequence
Some studies suggest that there is antigenic and nucleic acid homology of one type of non‐A, non‐B hepatitis virus with hepatitis B viral (HBV) proteins and DNA. Using molecular hybridisation under high and low stringency conditions with high specific activity 32 P‐HBV DNA as a probe, serum and liver samples from patients and nonhuman primates infected with non‐A, non‐B hepatitis were examined. Our results provide no evidence of significant homology between the DNA extracted from serum and liver of patients and nonhuman primates infected with one type of non‐A, non‐B hepatitis and HBV DNA.