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Experimental infection of tamarins with human non‐a, non‐b hepatitis virus
Author(s) -
Karayiannis P.,
Bamber M.,
Thomas H. C.,
Scheuer P. J.,
Cohn D.,
Hurn B. A. L.
Publication year - 1983
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890110308
Subject(s) - virology , inoculation , virus , biology , viral hepatitis , hepatitis , alanine aminotransferase , medicine , immunology , endocrinology
Non‐A, non‐B (NANB) viral hepatitis was successfully transmitted to two colonyborn Tamarins following inoculation with antihaemophilic factor VIII concentrate or the “H” inoculum. Both animals showed histological and ultrastructural evidence of viral hepatitis, with raised alanine aminotransferase (ALT) levels from the second week after inoculation through to the end of follow‐up, 5 months later.