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Interference between non‐a, non‐b and hepatitis b virus infection in chimpanzees
Author(s) -
Brotman Betsy,
Prince Alfred M.,
Huima Tellervo,
Richardson Linda,
Van Den Ende M. C.,
Pfeifer U.
Publication year - 1983
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890110303
Subject(s) - virology , hepatitis b virus , virus , viral interference , hepatitis b , viral replication , biology , immunology , medicine
Pre‐existing chronic or concurrent acute non‐A, non‐B (NANB) virus infection has been found to interfere with hepatitis B virus (HBV) replication and to delay and moderate markedly the appearance of disease related to HBV infection in chimpanzees. The mechanism for this phenomenon remains unclear. These findings are of practical significance for vaccine safety testing and evaluation of methods for virus inactivation in chimpanzees. The possible occurrence of dual NANB and HBV infection requires that prolonged follow‐up be carried out. Attempts to carry out inactivation studies on materials containing both types of virus may also provide misleading observations.