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Antibody response after application of a new live attenuated mumps vaccine (Pariorix®) measured by enzyme‐linked immunosorbent assay (ELISA)
Author(s) -
PopowKraupp Therese,
Kunz Christian,
Hofmann Hanns
Publication year - 1982
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890100206
Subject(s) - mumps virus , virology , mumps vaccine , hemagglutination assay , vaccination , antibody , medicine , hemolysis , hemagglutination , virus , immunology , titer , measles , rubella
Mumps virus specific antibody concentrations were determined by enzyme‐linked immunosorbent assay (ELISA), hemolysis‐in‐gel (HIG) test, and hemagglutination‐inhibition (HI) test in 17 adult volunteers before and after vaccination with a new live mumps vaccine, Pariorix®. The results of the present study indicate that the strain Urabe‐Am 9 of the mumps virus (Pariorix) induces antibodies in 100% of seronegative adults when measured by ELISA and in 70.6% and 64.7% in HIG and HI, respectively. ELISA is therefore a very sensitive and reliable method for the demonstration of sero‐conversion after vaccination. The vaccine was well tolerated and clinically acceptable in the group of adult volunteers.