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Immunogenicity in chimpanzees of experimental hepatitis B vaccines prepared from intact hepatitis B virus, purified polypeptides, or polypeptide micelles
Author(s) -
Tabor Edward,
Howard Colin R.,
Skelly Jacinta,
Snoy Philip,
Goudeau Alain,
Zuckerman Arie J.,
Gerety Robert J.
Publication year - 1982
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890100109
Subject(s) - immunogenicity , virology , antibody , antigen , titer , subclinical infection , virus , hepatitis b virus , hepatitis b , hepatitis , vaccination , hepatitis b vaccine , biology , medicine , immunology , hbsag
The immunogenicity of three experimental hepatitis B vaccines was evaluated in chimpanzees. Although no antibody to hepatitis B surface antigen (anti‐HBs) was detected in two chimpanzees that received an aqueous polypeptide vaccine subcutaneously, a strong anti‐HBs response was observed two and ten weeks, respectively, following challenge with hepatitis B virus. Inoculation of two additional chimpanzees with a micellar preparation of these polypeptides by the intravenous route resulted in anti‐HBs production in one of the chimpanzees. Two chimpanzees inoculated subcutaneously with an aqueous vaccine of formalin‐inactivated intact hepatitis B virus developed anti‐HBs in low titers, but the development of antibody to the hepatitis B core antigen following challenge inoculations suggested that subclinical HBV infections may have occurred despite prior vaccination.