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Non‐A, non‐b hepatitis: A case report
Author(s) -
Anderson Michael,
MurrayLyon Lain M.,
Coleman John C.,
McCaul Thomas F.,
Bird Richard G.,
Tovey George,
Zuckerman Arie J.
Publication year - 1982
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890090309
Subject(s) - endoplasmic reticulum , cytoplasm , golgi apparatus , hepatocyte , glycogen , pathology , ultrastructure , mitochondrion , nucleus , hepatocellular carcinoma , muscle hypertrophy , biology , hepatitis , biopsy , liver biopsy , microbiology and biotechnology , virology , medicine , biochemistry , endocrinology , cancer research , in vitro
Ultrastructural changes in a liver biopsy obtained for diagnostic purposes from a patient with suspected non‐A, non‐B hepatitis were consistent with hepatitis and included dilatation and disaggregation of the endoplasmic reticulum, hepatocyte disarray, and variations in mitochondrial size, In addition, some foci of hepatocytes showed atypical cytoplasmic changes including intranuclear cytoplasmic pseudo‐inclusions, consisting basically of invaginations of the cytoplasmic mass into the nucleus, glycogen deposits in the same nuclei, and frequently accumulations of fat droplets, The mitochondria were generally pleomorphic, and occasionally the mitochondria1 cristae were arranged longitudinally. Dilatation, hypertrophy, and distortion of the Golgi complexes were found in affected hepatocytes. Similar ultrastructural changes have previously been reported in human hepatocellular carcinoma as well as in carcinomas of other tissues.