Premium
Detection of human cytomegalovirus‐specific iga antibodies in colostrum by enzyme‐linked lmmunosorbent assay (elisa)
Author(s) -
Pinku Avraham,
Haikin Hava,
Friedman Maureen G.,
Sarov Israel
Publication year - 1982
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890090205
Subject(s) - colostrum , antibody , virology , cytomegalovirus , titer , immunology , immunoperoxidase , biology , antigen , human cytomegalovirus , virus , herpesviridae , viral disease , monoclonal antibody
Abstract Fifty women were examined after delivery for the prevalence of antibodies to human cytomegalovirus in colostrum and sera. Eighty percent of them had specific CMV IgG antibodies in the sera, as determined by the immunoperoxidase antibody to membrane antigen (IPAMA) technique. Of the CMV‐seropositive women, 60% had specific CMV IgA antibodies in high titer in the colostrum as determined by enzyme‐linked immunosorbent assay (ELISA). In only two of the seropositive women were specific CMV IgA antibodies detected in the sera as well. The significance of specific CMV IgA antibodies in colostrum as protection against perinatal infection and the mechanism of this production will be discussed.