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Specificity of hepatitis b virus affinity for human hepatic tissue
Author(s) -
Lutwick Larry I.,
Brenda Hebert M.,
Sklamberg Todd
Publication year - 1982
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890090204
Subject(s) - hepatitis b virus , woodchuck hepatitis virus , virology , hepatitis b , virus , biology , hepatitis , hepadnaviridae , kidney , antigen , microbiology and biotechnology , chemistry , immunology , endocrinology
Using radiolabeled purified hepatitis B surface anligen and human liver slices, the affinity of hepatitis B virus to its host organ was evaluated. Saturable adsorption of the l25 I‐HB S Ag complex to liver was demonstrated over both time and complex concentration which could be blocked by excess unlabeled antigen. The specific binding was not found using hurnan pancreas, lung, or kidney tissue. Correspondingly, no specific binding could be found for murine liver but it could be deinonslrated with woodchuck liver. The woodchuck is a natural host for one of the newly described hepatitis B‐like viruses which is antigenically cross‐reactive with the B virus.