Immunogenic effect of inactivated hepatitis B vaccine: Comparison of 20 μg and 40 μg doses | Zendy

Krugman Saul | Zendy; Holley H. Preston | Zendy; Davidson J. R. Morton | Zendy; Simberkoff Michael S. | Zendy; Matsaniotis Nicolas | Zendy

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Immunogenic effect of inactivated hepatitis B vaccine: Comparison of 20 μg and 40 μg doses

Author(s) -

Krugman Saul,

Holley H. Preston,

Davidson J. R. Morton,

Simberkoff Michael S.,

Matsaniotis Nicolas

Publication year - 1981

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890080205

Subject(s) - virology , medicine , hepatitis a vaccine , hepatitis b vaccine , inoculation , vaccination , hepatitis , immunology , hepatitis a , virus , hepatitis b virus , hbsag

The immunogenic effect of inactivated hepatitis B vaccine (Merck Heptavax B) was evaluated in 202 seronegative healthy medical personnel. Three inoculations of vaccine were given at 1‐month intervals. Of 116 vaccinees who received a 40‐μg dose, 39% had an anti‐HBs response 1 month after the first dose, 88% 1 month after the second dose, and 99% 1 month after the third dose. Of 86 vaccinees who received a 20‐μg dose, 40% had an anti‐HBs response 1 month after the first dose, 79% after the second dose, and 95% after the third dose. These results confirm the high immunogenic effect of a 20‐μg dose of vaccine.

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