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Immunogenic effect of inactivated hepatitis B vaccine: Comparison of 20 μg and 40 μg doses
Author(s) -
Krugman Saul,
Holley H. Preston,
Davidson J. R. Morton,
Simberkoff Michael S.,
Matsaniotis Nicolas
Publication year - 1981
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890080205
Subject(s) - virology , medicine , hepatitis a vaccine , hepatitis b vaccine , inoculation , vaccination , hepatitis , immunology , hepatitis a , virus , hepatitis b virus , hbsag
The immunogenic effect of inactivated hepatitis B vaccine (Merck Heptavax B) was evaluated in 202 seronegative healthy medical personnel. Three inoculations of vaccine were given at 1‐month intervals. Of 116 vaccinees who received a 40‐μg dose, 39% had an anti‐HBs response 1 month after the first dose, 88% 1 month after the second dose, and 99% 1 month after the third dose. Of 86 vaccinees who received a 20‐μg dose, 40% had an anti‐HBs response 1 month after the first dose, 79% after the second dose, and 95% after the third dose. These results confirm the high immunogenic effect of a 20‐μg dose of vaccine.