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Inhibition of influenza a virus replication by rifampicin and selenocystamine
Author(s) -
And Mansoor Hamzehei,
Ledinko Nada
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890060210
Subject(s) - embryonated , rifampicin , virology , microgram , virus , in vitro , microbiology and biotechnology , biology , rna polymerase , influenza a virus , antibiotics , viral replication , rna , chemistry , gene , biochemistry
The effects of selenocystamine, an inhibitor of influenza virus RNA‐dependent RNA polymerase in vitro activity, and the antibiotic rifampicin were studied on influenza A/PR/8/34 (HON1) infection in embryonated eggs. Both drugs completely inhibited hemagglutinating and infective virus yields when added at relatively early times postinfection. Maximal inhibition was produced by apparently noncytotoxic concentrations of 50 m̈g of selenocystamine, or of 400 m̈g of rifampicin, per egg.