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Studies in man with cold‐recombinant influenza virus (h1n1) live vaccines
Author(s) -
Reeve P.,
Gerendas Batia,
E. Liehl A. Moritz,
H. Hofmann C.Kunz,
Maassab H. F.
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890060110
Subject(s) - virology , viral shedding , antibody , virus , vaccination , biology , antibody response , immunology , transmission (telecommunications) , medicine , electrical engineering , engineering
Two cold‐recombinant influenza A (H1N1) viruses were tested in several groups of human volunteers. Only minor clinical symptoms were seen and no febrile reactions occurred. With serologically primed individuals virus shedding was low, but a high proportion showed rises in serum antibody levels after vaccination and mean titres were high. With serologically unprimed volunteers shedding was high, about 75% yielding viruses but only at low titres and for a short duration. No revertant viruses were found and there was no evidence of transmission to potentially susceptible individuals housed in close contact to the vaccinees. Serum antibody responses with unprimed volunteers were, however, low. Only about one half showed increases in serum antibody titres after vaccination and mean titres were low. Nevertheless, challenge with live attenuated virus indicated a high degree of protection based on virological evidence of infection.