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Hepatitis b surface antigen production as a growth cycle‐related terminal event in plc/prf/5 hepatoma cells
Author(s) -
Copeland Jennifer A.,
Skelly Jacinta,
Mann George F.,
Howard Colin R.,
Zuckerman Arie J.
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890050310
Subject(s) - radioimmunoassay , antigen , virology , biology , cell , hepatitis b virus , microbiology and biotechnology , immunology , virus , biochemistry
The dynamics of hepatitis B surface antigen production by PLC/PRF/5 hepatoma cells were studied using a quantitative radioimmunoassay method. Maximum rates of antigen production were found in nutrient‐depleted, non‐dividing cultures and were temporally related to cytological changes preceding cell death. These results indicate that antigen production may be cell‐cycle related and represent a terminal event.