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Relationship between antigenic type of virus and antibody response in female patients with herpes genitalis
Author(s) -
Ozaki Yoshikatsu,
Ohashi Masami,
Kimura Edna Matiko,
Ishiguro Tatsuya
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890050309
Subject(s) - virology , virus , biology , antibody , serology , antigen , herpes genitalis , herpes simplex virus , neutralizing antibody , typing , microbiology and biotechnology , immunology , genital herpes
The antigenic types of virus recovered from genital sites in cases of adult female genital herpes and antibody response in these patients were investigated. Twelve strains were isolated from 23 clinical specimens, and half the number of the isolates was classified as type 1 virus and the remaining half as type 2 virus. The results of serological typing corresponded well to biological differentiation by plaque‐forming ability on chick embryo cultures. The patients with type 1 virus infection had only the complement requiring neutralizing antibody, thus indicating a fresh infection. On the other hand, the noncomplement requiring neutralizing antibody was found in the patients with type 2 virus infection, indicating a later phase of infection.