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Cytomegalovlrus complement‐fixing igm antibody
Author(s) -
Booth J. C.,
Hannington Gillian,
Tryhorn Yvonne,
Stern H.
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890050303
Subject(s) - antigen , cytomegalovirus , antibody , virology , immunoglobulin m , biology , virus , chemistry , immunology , microbiology and biotechnology , herpesviridae , immunoglobulin g , viral disease
Abstract Cytomegalovirus (CMV)‐specific IgM that fixes complement in the presence of CMV antigen was demonstrated in sera from five patients with primary CMV infection. The CF reaction, demonstrable in the IgM fractions of the sera, was not affected significantly by absorption with aggregated IgG but was abolished by treatment with 2‐mercaptoethanol. The IgM antibody was readily detected in CF tests with crude cell‐extract antigens, prepared from CMV‐infected tissue culture cells, or with purified enveloped‐virion antigen but not with CMV‐soluble antigens.