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Small round virus‐like particles associated with acute gastroenteritis in japanese children
Author(s) -
Kogasaka Ryoichi,
Sakuma Yasuhiko,
Chiba Shunzo,
Akihara Minoru,
Horino Kyotaka,
Nakao Tooru
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890050209
Subject(s) - virology , acute gastroenteritis , virus , medicine
Nine patients with acute gastroenteritis shed small round virus‐like particles in the faeces, and seven of them developed serum antibody against those particles as judged by immune electron microscopy. The small round virus‐like particle was measured at 29–32 nm in diameter and showed a fine spiky structure on the surface. The buoyant density of the small round virus‐like particles was determined to be 1.37–1.40 gm/cm 3 in cesium chloride density gradient. The small round virus‐like particle differed morphologically from astrovirus and calicivirus, and was antigenically dissimilar to Norwalk agent and W agent. These observations suggest that the small round vims‐like particle is one of the new gastroenteritis viruses or may be a new serotype of them. Attempts to cultivate the small round virus‐like particles were unsuccessful.