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Antiviral activity of colostrum and serum immunoglobulins a and g
Author(s) -
Palmer E.L.,
Gary G.W.,
Black R.,
Martin M.L.
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890050205
Subject(s) - colostrum , virology , virus , antibody , titer , immunoglobulin a , neutralizing antibody , biology , immunoglobulin g , chemistry , immunology
Enteric virus‐specific IgA and IgG present in paired human sera and colostrums were measured by the enzyme‐linked immunosorbent assay (ELISA). Virus‐specific IgA was present in all colostrums, but virus‐specific IgG could not be detected. The reverse was true when sera were assayed. Most of these colostrums also neutralized either polio virus or reovirus, as did IgA, which was separated from a pool of colostrums by exclusion chromatography. No correlation could be made between levels of neutralizing and ELISA antibody titers in colostrums.