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Tubular structures in the cervix of mice experimentally infected with herpes simplex virus type 2
Author(s) -
Iwasaka Tsuyoshi,
Oda Hiroshi,
Hino Yuwao,
Mori Ryoichi
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890050204
Subject(s) - virology , herpes simplex virus , cervix , virus , uterine cervix , alphaherpesvirinae , biology , genital herpes , simplexvirus , herpesviridae , viral disease , carcinoma , genetics , cancer
Experimental infection of the C3H/N mouse genital tract was demonstrated after intravaginal inoculation with herpes simplex virus type 2 (HSV‐2). About 75% of the infected animals died by Day 7, and 75% of the surviving animals had severe vaginitis or neurological signs on Day 7. Titers of the virus recovered from vaginal secretions of infected animals reached a maximum on Day 2 and gradually decreased until Day 7. On the other hand, under the electron microscope, virus particles and tubular structures could be found in the nuclei of infected cells of the cervix in the 1st, 2nd and 4th days after infection. All cases in which virus particles could be found in the nuclei of infected cells were also positive for tubular structures and vice versa. These observations indicate that in situ diagnosis of HSV‐2 infection can be made in the mouse model. The same method would be applicable for the diagnosis of human HSV‐2 infection.