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Immunoglobulins to tick‐borne encephalitis in the cerebrospinal fluid of man
Author(s) -
Hofmann H.,
FrischNiggemeyer W.,
Heinz F.,
Kunz Ch.
Publication year - 1979
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890040310
Subject(s) - cerebrospinal fluid , antibody , tick borne encephalitis , encephalitis , meningitis , virology , immunology , medicine , antigen , specific antibody , virus , pathology , psychiatry
Antibodies of IgM and IgG type were detected in the CSF of patients with recent tick‐borne encephalitis (TBE) by means of ELISA. No false‐positive results were obtained with CSF specimens from patients suffering from meningitis or other illnesses. The ratio of the antibodies in serum to CSF clearly indicated that both IgM and IgG antibodies were produced in the brain itself. In patients who had previously suffered from TBE now with a different in‐aseptic meningitis, TBE antibodies could also be detected in CSF but only of the IgG class. Again the serum‐to‐CSF antibody ratio indicated that the antibodies were produced within the central nervous system. For routine diagnosis the micro‐ELISA method was found to be useful; antigen‐coated plates can be stored as long as three months at +4°C.