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Ebola and marburg viruses: II. Their development within vero cells and the extra‐cellular formation of branched and torus forms
Author(s) -
Ellis D. S.,
Stamford Susan,
Tovey D. G.,
Lloyd G.,
Bowen E. T. W.,
Platt G. S.,
Way Hilary,
Simpson D. I. H.
Publication year - 1979
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890040307
Subject(s) - vero cell , virology , marburg virus , biology , virus , ebola virus
The development of Marburg virus and the Sudanese and Zaire strains of Ebola virus in Vero cells as visualized by electron microscopy is described. Despite differences in timing, all three strains appear to pass through identical stages of development. Initially there is a large increase in nucleolus material, and viral precursor material arranges itself in spirals and then into tubes. The cells fill with core material, which passes to the plasmalemma, which often proliferates. Each virion passes through the plasmalemma, acquiring a coat of host material. The formation of torus forms is discussed; the branched appearance that is often seen is believed to be an aberrant form. The reasons for this view are put forward.