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Deeper insight into HBsAg — anti‐albumin antibody correlations
Author(s) -
Lenkei R.,
Babe¸ V. T.,
Mustea A.,
Dobre I.
Publication year - 1979
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890040208
Subject(s) - hbsag , titer , antibody , albumin , medicine , virology , asymptomatic , immunology , antibody titer , hepatitis b virus , virus
The presence and titers of anti‐albumin antibodies (AAA) — ie, precipitins (AA‐IP) and agglutinins (AA‐Aggl) — and the serum concentrations of immunoglobulins and albumin were determined in 210 asymptomatic carriers of HBsAg grouped according to HBsAg titer and subtype. A different immunologic pattern was observed in the HBsAg/ad and HBsAg/ay carriers, the results suggesting an increased aggressivity for the HBsAg/ay subtype which was more evident in subjects with lower HBs antigenemia and characterized by higher concentrations of IgG and IgM and rises in AA‐P titers. A positive linear correlation was found between HBsAg and AA‐Aggl titers; the carriage of HBsAg/ad was associated with significant higher values of AA‐Aggl than of HBsAg/ay. These subtle correlations between HBsAg titer and subtype and AAA suggest that the human serum albumin (HSA) known to exist on the HBsAg particles may be similar in a modified form, to that representing AAA specificity.