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ECHOvirus 33 replication in human peripheral white blood cells
Author(s) -
Gnann John W.,
Hayes Edward C.,
Smith Joan Z.,
Wilfert Catherine M.
Publication year - 1979
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890030407
Subject(s) - echovirus , peripheral blood mononuclear cell , virology , in vitro , virus , antibody , biology , cerebrospinal fluid , enterovirus , immunology , biochemistry , neuroscience
ECHOvirus 33 isolated from the cerebrospinal fluid of a patient with agammaglobulinemia was shown to replicate in vitro in peripheral leukocyte suspensions from a normal antibody negative donor. Replication was demonstrated by use of sequential dilution experiments. Washed glass adherent mononuclear cell cultures from a normal antibody negative donor were also capable of supporting ECHOvirus 33 replication in vitro. Leukocyte suspensions from the infected agammaglobulinemic patient extinguished detectable infectious virus in vitro.