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Experiences with radioimmunoassay in the detection of HBsAg in the presence of anti‐HBs
Author(s) -
Siebke JensChristian
Publication year - 1978
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890030109
Subject(s) - radioimmunoassay , hbsag , virology , antibody , chemistry , medicine , immunology , virus , hepatitis b virus , biochemistry
Interference from anti‐HBs present during hepatitis B antigenemia caused the appearance of several false negative reactions in a competition radioimmuno‐precipitation procedure. The results indicate that such interference is considerably less in the solid‐phase radioimmunoassay (Ausria II) and probably causes few false negative tests. The use of pepsin treatment as a means to destroy interfering antibodies is discussed.