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Steroid hormone alteration of herpes simplex virus type 1 replication
Author(s) -
Notter Mary F. D.,
Docherty John J.
Publication year - 1978
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890020308
Subject(s) - herpes simplex virus , virus , virology , biology , viral replication , hormone , plating efficiency , steroid , steroid hormone , dna , cell , microbiology and biotechnology , biochemistry
The effect of steroid hormones on herpes simplex virus type 1 replication was examined. Virus replication studies revealed that various concentrations of prednisolone, hydrocortisone, dexamethasone, or progesterone could decrease virus yields up to a maximum of 99%. Using isopycnic centrifugation in CsCl to separate viral from cell DNA, it was found that virus‐specific DNA synthesis was decreased by 30 to 100% depending on the hormone and concentration used. Cell‐specific DNA synthesis was also adversely affected, but this did not alter cell viability or plating efficiency.