Premium
Effects of phosphonoacetic acid on subacute myeloopticoneuropathy virus in vitro and in vivo
Author(s) -
Nishibe Y.,
Inoue Y. K.
Publication year - 1978
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890020306
Subject(s) - in vivo , virology , in vitro , virus , incubation , incubation period , biology , microbiology and biotechnology , chemistry , biochemistry
The effect of phosphonoacetic acid (PAA) in vitro and in vivo on subacute myeloopticoneuropathy (SMON) virus isolated from the spinal fluid of SMON patients was studied. PAA inhibited multiplication of SMON virus in cultures, but it did not show a direct effect on the virus. The drug did not influence the disease when the medication was started from 10 days after infection of suckling mice. However, the drug did elicit a delay in the incubation period.