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Solid‐phase microtiter radioimmunoassay for detection of the Norwalk strain of acute nonbacterial, epidemic gastroenteritis virus and its antibodies
Author(s) -
Greenberg Harry B.,
Wyatt Richard G.,
Valdesuso Jose,
Kalica Anthony R.,
London William T.,
Chanock Robert M.,
Kapikian Albert Z.
Publication year - 1978
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890020204
Subject(s) - radioimmunoassay , virology , microtiter plate , antigen , antibody , immune system , virus , immune adherence , chemistry , biology , chromatography , immunology , hemagglutination , biochemistry
Abstract The development of microtiter solid‐phase radioimmunoassays for the detection of Norwalk antigen and its antibody is described. The tests are simple to perform and are sensitive and specific. The test for antigen can be used on crude stool filtrates and suspensions. Both tests are at least as sensitive as immune electron microscopy and more sensitive than immune adherence assay.