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Experimental respiratory syncytial virus infection of four species of primates
Author(s) -
Belshe Robert B.,
Richardson Linda S.,
London William T.,
Sly D. Lewis,
Lorfeld John H.,
Camargo Ena,
Prevar David A.,
Chanock Robert M.
Publication year - 1977
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890010302
Subject(s) - virus , virology , titer , respiratory system , biology , squirrel monkey , paramyxoviridae , pneumovirinae , viral disease , immunology , neuroscience , anatomy
Abstract Four species of nonhuman primates were inoculated intranasally with 10 3.1 to 10 3.7 plaque forming units (pfu) of respiratory syncytial (RS) virus. Adult squirrel monkeys and newborn rhesus monkeys became infected and shed small quantities (peak titer 10 2.0 pfu/ml of nasopharyngeal swab specimen) of virus, but illness did not develop. Infant cebus monkeys aged 2 months became infected, shed 10 2.3 to 10 3.8 pfu/ml of nasopharyngeal swab specimen, but did not become ill. Chimpanzees aged 15 to 18 months shed a large quantity of virus, up to 10 6.0 pfu/ml of nasopharyngeal swab specimen and developed an upper respiratory illness. Chimpanzees are proposed as a possible animal model for future study of the immunopathology of RS virus desease and for in vivo evaluation of attendated live virus vaccine candidates.