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Correlations between anti‐albumin antibodies and HB s AG in hepatic patients
Author(s) -
Lenkei R.,
Babes V. T.,
Dan M. E.,
Mustea A.,
Dobre I.
Publication year - 1977
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890010106
Subject(s) - antibody , precipitin , hbsag , medicine , ouchterlony double immunodiffusion , hemagglutination , autoantibody , cold agglutinin , immunodiffusion , immunology , albumin , hepatic function , hepatitis b , hepatitis , virology , gastroenterology , hepatitis b virus , virus , antiserum
A new category of autoantibodies ‐ antipolymerized albumin antibodies (AAA) ‐ was discovered in 1974. Studies performed from 1974 to 1976 showed their diagnosis and prognostic values in hepatic diseases; the AAA tests [immunodiffusion (ID) and hemagglutination (HS)] made possible a good estimation of the total liver cell function. Without being specific for a viral hepatitis B infection, highly significant linear correlations were found for AAA precipitin and agglutinin positivities with presence of HB s Ag. High titre of AAA agglutinins unaccompanied by a positive ID test, characterise the “healthy carrier” of the HB s Ag, while the isolated AAA positivity in ID is met in more severe, long‐standing hepatic diseases.