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Cytomegalovirus as a frequent cause of Guillain‐Barré syndrome
Author(s) -
Schmitz H.,
Enders G.
Publication year - 1977
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890010105
Subject(s) - cytomegalovirus , titer , virology , antibody , guillain barre syndrome , medicine , immunofluorescence , virus , immunology , indirect immunofluorescence , cytomegalovirus infections , immunoglobulin m , herpesviridae , human cytomegalovirus , viral disease , immunoglobulin g
In 10 patients with Guillain‐Barré syndrome a preceeding cytomegalovirus infection could be demonstrated by virus‐specific IgM antibodies that were present in high titers in 9 of the 10 patients in the first serum specimen. The IgM antibodies to cytomegalovirus were detected by a sensitive “double” indirect immunofluorescence technique. In most of our cases (8 of 10) the complement‐fixing antibody titers had already reached high levels on admission into a hospital, and significant titer changes were not observed. Cytomegalovirus was isolated from the urine of five patients.