Premium
High prevalence of TT virus‐related DNA (90%) and diverse viral genotypes in norwegian blood donors
Author(s) -
Huang LiYue,
Jonassen Tom Øystein,
Hungnes Olav,
Grinde Bjørn
Publication year - 2001
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1062
Subject(s) - virology , norwegian , viremia , genotype , virus , biology , viral disease , genetics , gene , philosophy , linguistics
Early estimates of the prevalence of TTV viremia in healthy adults of developed countries were in the order of 1–10 %, while similar estimates in Third World countries were considerably higher. Using three different PCRs, TTV‐related DNA was detected in serum from 180 out of the 201 Norwegian blood donors tested, indicating that these viruses are almost universally present in adults. Sequence analysis revealed heterogeneity similar to what is found world‐wide. The data suggest that the previous discrepancy in prevalences might be related to a lower serum concentration of virus in developed countries. The high prevalence adds evidence to the benign nature of the virus. J. Med. Virol. 64:381–386, 2001. © 2001 Wiley‐Liss, Inc.