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Genetic variation in the VP7 gene of human rotavirus isolated in Montevideo‐Uruguay from 1996–1999
Author(s) -
Berois Mabel,
Libersou Sonia,
Russi José,
Arbiza Juan,
Cohen Jean
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10511
Subject(s) - serotype , rotavirus , virology , biology , gene , reoviridae , homology (biology) , diarrhea , virus , genetics , medicine
Abstract The gene encoding the protein VP7 that induces the major neutralizing response has been sequenced from 34 human rotaviruses isolated from children with acute diarrhea in Montevideo (Uruguay) over a 4‐year period (1996–1999). These sequences were analyzed and compared to representative corresponding sequences available on databases. In most years, serotype G1 was present as the single serotype, except in 1999 when serotypes G1 and G4 were present simultaneously. Two G1 VP7 lineages were identified. Serotype G2 was present in 1997. The G4 isolates are grouped with Argentine strains and emerged during 1998 in a recently defined sublineage. Neither serotype G3 nor the emerging serotype G9 were isolated during the study. Antigenic domains of isolates and of representative reference strains of each serotype were compared. Sequences of strains isolated during the same year, showed a high degree of homology among strains belonging to the same serotype. J. Med. Virol. 71:456–462, 2003. © 2003 Wiley‐Liss, Inc.