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Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolates from patients with chronic HBV infection in Korea
Author(s) -
Odgerel Zagaa,
Nho Kyung Bo,
Moon Ju Young,
Kee Sun Ho,
Park Kwang Sook,
Song KiJoon,
Baek Luck Ju,
Yeon Jong Eun,
Byun Kwan Soo,
Lee Chang Hong,
Song JinWon
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10506
Subject(s) - virology , hepatitis b virus , biology , phylogenetic tree , genotype , genome , sequence analysis , virus , nucleic acid sequence , genomic dna , gene , genetics
Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV. J. Med. Virol. 71:499–503, 2003. © 2003 Wiley‐Liss, Inc.