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Multicentric Castleman's disease treated with antivirals and immunosuppressants
Author(s) -
Senanayake Sanjaya,
Kelly John,
Lloyd Andrew,
Waliuzzaman Zubair,
Goldstein David,
Rawlinson William
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10500
Subject(s) - medicine , chemotherapy , sarcoma , human herpesvirus , antiviral therapy , disease , virology , human immunodeficiency virus (hiv) , castleman disease , viral disease , immunology , virus , kaposi's sarcoma , immunopathology , pathology , chronic hepatitis
A patient negative for human immunodeficiency virus (HIV) developed multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) associated with active human herpesvirus 8 (HHV‐8) infection. He was treated with sequential antiviral therapy, chemotherapy, and corticosteroids. HHV‐8 levels were monitored throughout the course of the patient's illness, and were found to rise on relapse. No consistent change in HHV‐8 levels was found with antiviral therapy. We demonstrate that in this patient antiviral therapy was clinically ineffective, and did not alter HHV‐8 levels, but that corticosteroid and combination chemotherapy led to clinical improvement. Despite the implication of HHV‐8 as a cause of MCD, few studies have correlated HHV‐8 levels with clinical response. J. Med. Virol. 71:399–403, 2003. © 2003 Wiley‐Liss, Inc.