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Genital human papillomavirus genotyping by HPV oligonucleotide microarray in Korean commercial sex workers
Author(s) -
Choi ByeongSun,
Kim Okjin,
Park Mi Sun,
Kim Ki Soo,
Jeong Jeongmi Kim,
Lee JooShil
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10498
Subject(s) - genotype , genotyping , sex organ , virology , human papillomavirus , hpv infection , biology , population , hpv vaccines , epidemiology , molecular epidemiology , medicine , genetics , cervical cancer , gene , cancer , environmental health
Because of the diversity in human papillomavirus (HPV) distribution, according to the population and region, detailed investigations of HPV genotypes are important in designing more effective HPV vaccines for any given country. HPV DNA oligonucleotide microarray was used to investigate the distribution of HPV genotypes among commercial sex workers. The prevalence of HPV in Korean commercial sex workers was 47%, with HPV‐16 and HPV‐51 as the dominant genotypes. HPV subtypes in 148 commercial sex workers comprised 70 with one genotype, 42 with two genotypes, 17 with three genotypes, and 19 with four or more genotypes. HPV‐40, the most dominant low‐risk genotype, was not detected in single‐infection commercial sex workers. All women with multiple infections of low‐risk genotypes had the HPV‐40 genotype. This molecular epidemiological study of genital HPV will be useful for the development of a favorable strategy to prevent the spread of this potentially serious infection. J. Med. Virol. 71:440–445, 2003. © 2003 Wiley‐Liss, Inc.