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Antigenic and genetic variability of human respiratory syncytial viruses (group A) isolated in Uruguay and Argentina: 1993–2001
Author(s) -
Frabasile Sandra,
Delfraro Adriana,
Facal Luján,
Videla Cristina,
Galiano Mónica,
de Sierra María José,
Ruchansky Dora,
Vitureira Nathalia,
Berois Mabel,
Carballal Guadalupe,
Russi José,
Arbiza Juan
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10484
Subject(s) - biology , phylogenetic tree , epitope , virology , genotype , genetic diversity , antigen , strain (injury) , genetic variability , antigenic variation , glycoprotein , gene , monoclonal antibody , phylogenetics , genetic variation , genetics , virus , antibody , population , anatomy , demography , sociology
The antigenic and genetic diversity of G glycoprotein from 25 human respiratory viruses (group A) isolated during nine consecutive epidemics (1993–2001) in Montevideo, Uruguay, and 7 strains isolated in Buenos Aires, Argentina, in the same period were analyzed. Genetic variability was evaluated by partial sequence of the G protein gene. Phylogenetic analysis indicated that most Uruguayan and Argentinean group A isolates clustered into three genotypes: GA5, GA2, and GA1. Some strains clustered into the GA3 genotype characterized previously. The antigenic analysis was carried out with a panel of anti‐G monoclonal antibodies that recognized conserved and strain‐specific epitopes. A close correlation between the antigenic and genetic relatedness of the strains analyzed was observed. J. Med. Virol. 71:305–312, 2003. © 2003 Wiley‐Liss, Inc.