Antigenic and genetic variability of human respiratory syncytial viruses (group A) isolated in Uruguay and Argentina: 1993–2001 | Zendy

Frabasile Sandra | Zendy; Delfraro Adriana | Zendy; Facal Luján | Zendy; Videla Cristina | Zendy; Galiano Mónica | Zendy; de Sierra María José | Zendy; Ruchansky Dora | Zendy; Vitureira Nathalia | Zendy; Berois Mabel | Zendy; Carballal Guadalupe | Zendy; Russi José | Zendy; Arbiza Juan | Zendy

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Antigenic and genetic variability of human respiratory syncytial viruses (group A) isolated in Uruguay and Argentina: 1993–2001

Author(s) -

Frabasile Sandra,

Delfraro Adriana,

Facal Luján,

Videla Cristina,

Galiano Mónica,

de Sierra María José,

Ruchansky Dora,

Vitureira Nathalia,

Berois Mabel,

Carballal Guadalupe,

Russi José,

Arbiza Juan

Publication year - 2003

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.10484

Subject(s) - biology , phylogenetic tree , epitope , virology , genotype , genetic diversity , antigen , strain (injury) , genetic variability , antigenic variation , glycoprotein , gene , monoclonal antibody , phylogenetics , genetic variation , genetics , virus , antibody , population , anatomy , demography , sociology

The antigenic and genetic diversity of G glycoprotein from 25 human respiratory viruses (group A) isolated during nine consecutive epidemics (1993–2001) in Montevideo, Uruguay, and 7 strains isolated in Buenos Aires, Argentina, in the same period were analyzed. Genetic variability was evaluated by partial sequence of the G protein gene. Phylogenetic analysis indicated that most Uruguayan and Argentinean group A isolates clustered into three genotypes: GA5, GA2, and GA1. Some strains clustered into the GA3 genotype characterized previously. The antigenic analysis was carried out with a panel of anti‐G monoclonal antibodies that recognized conserved and strain‐specific epitopes. A close correlation between the antigenic and genetic relatedness of the strains analyzed was observed. J. Med. Virol. 71:305–312, 2003. © 2003 Wiley‐Liss, Inc.

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