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Prevalence of anti‐human respiratory syncytial virus antibodies over three consecutive years in a healthy adult population
Author(s) -
Chala Silvia R.,
GarcíaBarreno Blanca,
Melero José A.,
Palomo Concepción
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10483
Subject(s) - antibody , virology , titer , virus , mononegavirales , population , respiratory system , paramyxoviridae , medicine , biology , epidemiology , cohort , immunology , pneumovirinae , viral disease , neutralizing antibody , environmental health
The titers of anti‐human respiratory syncytial virus (HRSV) antibodies have been measured by enzyme‐linked immunosorbent assay (ELISA) in a cohort of healthy adult volunteers over 3 consecutive years. Significant increases in the level of these antibodies were detected in a small percentage of individuals (3–3.3%), when paired serum samples taken from two consecutive seasons were compared. In these cases, a significant increase was generally noted in the level of antibodies directed against either the F or the G glycoproteins, and in the level of neutralizing antibodies. However, no correlation was found between the level of binding and neutralizing antibodies, when samples representative of the population under study were analyzed. These results indicate some level of infection by HRSV in the adult population. The implications of these results for the epidemiology of HRSV are discussed. J. Med. Virol. 71:298–304, 2003. © 2003 Wiley‐Liss, Inc.