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Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease
Author(s) -
Sugauchi Fuminaka,
Ohno Tomoyoshi,
Orito Etsuro,
Sakugawa Hiroshi,
Ichida Takafumi,
Komatsu Masafumi,
Kuramitsu Tomoyuki,
Ueda Ryuzo,
Miyakawa Yuzo,
Mizokami Masashi
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10428
Subject(s) - genotype , hepatitis b virus , liver disease , virology , hepatocellular carcinoma , hepadnaviridae , cirrhosis , orthohepadnavirus , biology , hepatitis b , mutant , virus , medicine , gene , genetics , biochemistry
Hepatitis B virus (HBV) mutants with deletions in the preS region have not been evaluated for association with viral genotypes. In a case‐control study, HBV DNA samples collected from 80 each of carriers infected with HBV genotype B or C were examined for preS deletions. PreS deletion mutants were found in a total of 37 of 160 (23%) HBV carriers. Carriers with preS deletion mutants were older (56.0 ± 12.7 vs 49.3 ± 16.9 years, P < 0.05), were infected more frequently with HBV genotype C (84% vs 40%, P < 0.05), and had more advanced disease, such as liver cirrhosis and hepatocellular carcinoma (54% vs 31%; P < 0.05), than did those without such mutants. In a multivariate analysis, genotype C (odds ratio [OR] = 9.3, P < 0.001) and advanced liver disease (OR = 3.1, P < 0.01) were the most significant variables in association with preS deletions. A direct repeat sequence (TCAGG) was found at the start or at the end of preS1 deletions in 6 of the 20 (30%) cases examined, and preS2 deletions in these cases were clustered over the 5′‐terminal half of this region. These results indicate that the development of preS deletion mutants depends on HBV genotypes and that it may be associated with progressive liver disease. J. Med. Virol. 70:537–544, 2003. © 2003 Wiley‐Liss, Inc.