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Human herpesvirus 7‐associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation
Author(s) -
Yoshikawa Tetsushi,
Yoshida Jun,
Hamaguchi Motohiro,
Kubota Toshinobu,
Akimoto Shiho,
Ihira Masaru,
Nishiyama Yukihiro,
Asano Yoshizo
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10414
Subject(s) - medicine , human herpesvirus 6 , aseptic meningitis , transplantation , optic neuritis , meningitis , vomiting , lymphocytic pleocytosis , cerebrospinal fluid , csf pleocytosis , immunology , herpesviridae , virology , gastroenterology , encephalitis , surgery , multiple sclerosis , viral disease , virus
A 9‐year‐old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation. In addition to vomiting, the patient had a fever (from day 26) and severe headache (from day 34). His cerebrospinal fluid (CSF) (day 41) demonstrated pleocytosis with an absence of leukemic cells. Although the patient's symptoms were resolved with further supportive care, abrupt onset of bilateral decreased vision occurred at day 54. He was diagnosed with bilateral optic neuritis, due to the presence of disc edema and redness. Concomitant with the occurrence of aseptic meningitis, the human herpesvirus 7 (HHV‐7) antibody titer increased significantly in this patient. Although neither HHV‐6 nor cytomegalovirus (CMV) DNA was detected in CSF collected at day 41, HHV‐7 DNA was detected in the sample. Viral DNA was not detected in CSF collected at day 93. J. Med. Virol. 70:440–443, 2003. © 2003 Wiley‐Liss, Inc.