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Dynamics of Epstein‐Barr virus load in pyothorax‐associated lymphoma
Author(s) -
Shide Kotaro,
Henzan Hideho,
Nagafuji Koji,
Aoki Kenichi,
Miyamoto Toshihiro,
Shimoda Kazuya,
Kazuyama Yukumasa,
Ohshima Koichi,
Gondo Hisashi,
Harada Mine
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10374
Subject(s) - lymphoma , chemotherapy , medicine , virus , rituximab , epstein–barr virus , lactate dehydrogenase , polymerase chain reaction , diffuse large b cell lymphoma , radiation therapy , virology , pathology , biology , gene , biochemistry , enzyme
Abstract We treated a 73‐year‐old man who developed a pyothorax‐associated pleural lymphoma after a 52‐year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B‐cell type. Epstein‐Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real‐time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax‐associated lymphoma. J. Med. Virol. 70:137–140, 2003. © 2003 Wiley‐Liss, Inc.