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Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir
Author(s) -
Koonsaeng Suphannee,
Verschraegen Claire,
Freedman Ralph,
Bossens Michel,
Kudelka Andrzej,
Kavanagh John,
Sittisomwong Tul,
DeClercq Erik,
Snoeck Robert
Publication year - 2001
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1036
Subject(s) - cidofovir , isotretinoin , virology , medicine , human papillomavirus , interferon , vulvar intraepithelial neoplasia , dermatology , intraepithelial neoplasia , virus , vulva , acne , cancer , prostate
Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43‐year‐old woman with a 20‐year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia. J. Med. Virol. 64:195–198, 2001. © 2001 Wiley‐Liss, Inc.