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Cellular factors and IE62 activation of VZV promoters
Author(s) -
Ruyechan William T.,
Peng Hua,
Yang Min,
Hay John
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10328
Subject(s) - virology , promoter , biology , genetics , gene , gene expression
The varicella zoster virus IE62 protein transactivates promoters representing all three kinetic classes of viral genes. This is accomplished in conjunction with the general transcription machinery of the cell and specific cellular transcription factors that act at sites located within viral promoters. The incidence of a subset of specific recognition sites was examined for the ubiquitous cellular factors Sp1 and USF within the VZV genome. Evidence is also presented for a direct physical interaction between Sp1 and IE62. J. Med. Virol. 70:S90–S94, 2003. © 2003 Wiley‐Liss, Inc.