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Case report: Kinetics of Epstein‐Barr virus load in a bone marrow transplant patient with no sign of lymphoproliferative disease
Author(s) -
Biasolo Maria Angela,
Calistri Arianna,
Cesaro Simone,
Gentile Giuseppe,
Mengoli Carlo,
Palù Giorgio
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10285
Subject(s) - lymphoproliferative disease , epstein–barr virus , lymphoproliferative disorders , context (archaeology) , viral load , immunology , medicine , bone marrow , virology , virus , peripheral blood mononuclear cell , lymphoproliferative response , herpesviridae , disease , viral disease , pathology , biology , lymphoma , in vitro , paleontology , biochemistry
The kinetics of Epstein‐Barr virus (EBV) load was measured in peripheral blood mononuclear cells of a severely immunocompromised allogeneic bone marrow recipient child, in conditions not associated with lymphoproliferative disease. The viral doubling time was 46.4 hr. The study permitted monitoring EBV clearance from blood, when the anti‐rejection therapy was interrupted. Likely, this is the first accurate kinetic assessment of EBV load increasing phase in a clinical context marked by the absence of an overt post‐transplant lymphoproliferative disease. According to these data γ‐herpesviruses behave like β‐herpesviruses in being capable of rapid growth. J. Med. Virol. 69:220–224, 2003. © 2003 Wiley‐Liss, Inc.