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Human papillomavirus DNA detection in the management of women with twice mildly abnormal cytological smears
Author(s) -
Ho Linda,
Terry George,
Londesborough Philip,
Cuzick Jack,
Lorenzato Felipe,
Singer Albert
Publication year - 2003
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10257
Subject(s) - cytology , medicine , human papillomavirus , gynecology , cervical cancer , obstetrics , cancer , pathology
This study was undertaken to investigate the value of HPV testing in women referred with two abnormal smears that were graded as mild dyskaryosis or less who attended for at least three follow‐up visits. One hundred forty‐nine women were included in the study and a total of 39 high‐grade lesions including one cancer were detected. All of these were found to be associated with the persistent presence of one or more of 13 high‐risk human papillomavirus types (HPV) as detected by a multiplex type specific PCR technique. Two high‐grade lesions were initially missed by cytology. In contrast, no cytological or histological evidence of high‐grade lesions was found during a follow‐up period of up to 8 years in 62 women with no high‐risk HPV infection or in 38 women with only transient high‐risk HPV infection. The utility of high‐risk HPV detection in the management of women presenting with mild cytological abnormalities is discussed. J. Med. Virol. 69:118–121, 2003. © 2003 Wiley‐Liss, Inc.