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Characterization of measles sequences from Pune, India
Author(s) -
Wairagkar Niteen,
Rota Paul A.,
Liffick Stephanie,
Shaikh Naseem,
Padbidri V.S.,
Bellini William J.
Publication year - 2002
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10228
Subject(s) - virology , measles , genotype , measles virus , biology , mononegavirales , outbreak , genetic diversity , morbillivirus , polymerase chain reaction , sequence analysis , paramyxoviridae , gene , virus , viral disease , genetics , medicine , vaccination , population , environmental health
The goal of this study was to conduct the initial genetic characterization wild‐type measles viruses currently circulating in India. Reverse transcription‐polymerase chain reaction detected measles RNA in 11 of 14 throat swabs collected from sporadic and outbreak‐associated cases in the city of Pune, during 1996–1998. Sequence analysis of the H and N genes showed that six sequences were genotype D4, three were genotype D8, and two were genotype A. Continued virologic surveillance in other areas of India as well as neighboring countries will indicate the extent of genetic diversity present among wild‐type measles viruses circulating in India. J. Med. Virol. 68:611–614, 2002. © 2002 Wiley‐Liss, Inc.