Human antibody response to Toscana virus glycoproteins expressed by recombinant baculovirus | Zendy

Di Bonito Paola | Zendy; Bosco Simona | Zendy; Mochi Stefania | Zendy; Accardi Luisa | Zendy; Ciufolini Maria G. | Zendy; Nicoletti Loredana | Zendy; Giorgi Colomba | Zendy

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Human antibody response to Toscana virus glycoproteins expressed by recombinant baculovirus

Author(s) -

Di Bonito Paola,

Bosco Simona,

Mochi Stefania,

Accardi Luisa,

Ciufolini Maria G.,

Nicoletti Loredana,

Giorgi Colomba

Publication year - 2002

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.10227

Subject(s) - virology , glycoprotein , recombinant dna , virus , western blot , recombinant virus , biology , nucleoprotein , antibody , baculoviridae , immune system , humoral immunity , antigen , viral envelope , microbiology and biotechnology , immunology , gene , spodoptera , biochemistry

The arthropod‐borne Toscana virus has been associated with acute neurological disease in humans. In this study, the viral envelope glycoproteins were expressed in soluble form in a baculovirus system. The recombinant sGN and sGC proteins were used as viral antigens in a Western blot assay to analyze the specific immune response in sera from patients with recognized virus‐associated aseptic meningitis. The anti‐glycoprotein and the anti‐nucleoprotein N IgG responses were compared by an immunoassay based on the recombinant proteins. In this system, all the sera showed a high reactivity to the N protein, but they differed in the response to the glycoproteins. J. Med. Virol. 68:615–619, 2002. © 2002 Wiley‐Liss, Inc.

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