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Prolonged shedding of rotavirus in a geriatric inpatient
Author(s) -
Mori Isamu,
Matsumoto Kazuo,
Sugimoto Kazunori,
Kimura Makiko,
Daimon Nagomu,
Yokochi Takashi,
Kimura Yoshinobu
Publication year - 2002
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10147
Subject(s) - rotavirus , virology , viral shedding , polymerase chain reaction , reverse transcriptase , immune system , reverse transcription polymerase chain reaction , virus , medicine , rotavirus infections , antigen , immunology , biology , gene , messenger rna , biochemistry
Abstract This study concerns a nosocomial rotaviral infection of a geriatric patient with clinical symptoms of acute gastroenteritis. The virological diagnosis was based on the detection of rotaviral antigens using a Rota kit, viral genome RNA by reverse transcription‐polymerase chain reaction method, and viral particles by electron microscopy in the stool samples. Prolonged rotaviral shedding was suggested to be due to impaired natural killer cell activity, possibly together with deficiency of specific local immune response of the patient. J. Med. Virol. 67:613–615, 2002. © 2002 Wiley‐Liss, Inc.