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Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi
Author(s) -
Cunliffe Nigel A.,
Dove Winifred,
Gondwe Jailosi S.,
Thindwa Benson D.M.,
Greensill Julie,
Holmes Jennifer L.,
Bresee Joseph S.,
Monroe Stephan S.,
Glass Roger I.,
Broadhead Robin L.,
Molyneux Malcolm E.,
Hart C. Anthony
Publication year - 2002
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.10139
Subject(s) - astrovirus , virology , genotype , concomitant , medicine , human immunodeficiency virus (hiv) , virus , pediatrics , biology , rotavirus , gene , biochemistry
In a 2‐year hospital‐based study of paediatric gastroenteritis in Blantyre, Malawi, astroviruses were detected by enzyme immunoassay in 15 (1.9%) of 786 inpatients and in 9 (2.3%) of 400 outpatients. Greater disease severity was noted in children coinfected with human immunodeficiency virus (HIV). Six human astrovirus (HAstV) genotypes were identified, including HAstV‐1 (25%), HAstV‐2 (21%), HAstV‐3 (25%), HAstV‐4 (13%), HAstV‐5 (4%), and HAstV‐8 (13%). Although astroviruses are not major causes of gastroenteritis among children admitted to hospital in Blantyre, concomitant HIV infection appears to be a risk factor for increased severity of disease. J. Med. Virol. 67:563–566, 2002. © 2002 Wiley‐Liss, Inc.