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Electrospray ionization mass spectrometry study on dipeptide 4‐chlorobutyl ester produced from refluxing of amino acid with phosphoryl chloride in tetrahydrofuran
Author(s) -
Zhou Gui Ji,
Liu Ze,
Wang Tong Jian,
Xu Peng Xiang,
Tang Gou,
Ye Yong,
Zhao Yu Fen
Publication year - 2005
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.918
Subject(s) - chemistry , tetrahydrofuran , dipeptide , electrospray ionization , mass spectrometry , chloride , tandem mass spectrometry , electrospray , organic chemistry , fast atom bombardment , lithium chloride , chromatography , peptide , biochemistry , solvent
Phosphoryl chloride was able to promote the formation of peptide and the ringopening of tetrahydrofuran (THF) followed by a sequence of successive reactions by simply refluxing. ESI multistage tandem mass spectrometry was applied to trace the reaction and elucidate the product structures, dipeptide 4‐chlorobutyl ester. Copyright © 2005 John Wiley & Sons, Ltd.